Optimization-Based Evaluation of Concentrations in Modeling the Biosensor-Aided Measurement
Volume 22, Issue 4 (2011), pp. 589–600
Pub. online: 1 January 2011
Type: Research Article
Received
1 September 2011
1 September 2011
Accepted
1 December 2011
1 December 2011
Published
1 January 2011
1 January 2011
Abstract
The concentration of a substrate in a solution can be measured using amperometric signals of biosensors: in fact the maximum (steady state) current is measured which is calibrated in the units of concentration. Such a simple method is not applicable in the case of several substrates. In the present paper, the problem of evaluation of concentrations of several substrates is tackled by minimizing the discrepancy between the observed and modeled transition processes of the amperometric signal.