Informatica

Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at risk. However, manual adjustment of the parameters involved in gEUD is required to ensure that the plans meet patient-specific physical restrictions. This paper proposes a radiotherapy planning methodology based on bi-level optimization. We evaluated the proposed scheme in a real patient and compared the resulting irradiation plans with those prepared by clinical planners in hospital devices. The results in terms of efficiency and effectiveness are promising.

Ligand Based Virtual Screening methods are used to screen molecule databases to select the most promising compounds for a query. This is performed by decision-makers based on the information of the descriptors, which are usually processed individually. This methodology leads to a lack of information and hard post-processing dependent on the expert’s knowledge that can end up in the discarding of promising compounds. Consequently, in this work, we propose a new multi-objective methodology called MultiPharm-DT where several descriptors are considered simultaneously and whose results are offered to the decision-maker without effort on their part and without relying on their expertise.

A new heuristic algorithm for solution of bi-objective discrete competitive facility location problems is developed and experimentally investigated by solving different instances of a facility location problem for firm expansion. The proposed algorithm is based on ranking of candidate locations for the new facilities, where rank values are dynamically adjusted with respect to behaviour of the algorithm. Results of the experimental investigation show that the proposed algorithm is suitable for the latter facility location problems and provides good results in sense of accuracy of the approximation of the true Pareto front.

This paper aims to extend fuzzy MULTIMOORA with linguistic reasoning and group decision-making (MULTIMOORA-FG). The new method consists of the three parts, namely the fuzzy Ratio System, the fuzzy Utopian Reference Point, and the fuzzy Full Multiplicative Form offering a robust comparison of alternatives against multiple objectives. In addition, MULTIMOORA-FG is designed to deal with triangular fuzzy numbers which, in turn, can resemble linguistic variables. MULTIMOORA-FG is a proper instrument for linguistic reasoning under fuzzy environment. In our study an application of personnel selection illustrates the group decision-making procedure according to MULTIMOORA-FG. Given the uncertainties peculiar of personnel selection, the application of multi-objective decision making (MODM) is required in this area. Fuzzy MULTIMOORA enables to aggregate subjective assessments of the decision-makers and thus offer an opportunity to perform a more robust personnel selection. The committee decided to consider eight qualitative characteristics expressed in linguistic variables. A numerical example exhibited possibilities for improvement of human resources management or any other business decision-making by applying MULTIMOORA-FG.

Multi-Objective Optimization takes care of different objectives with the objectives keeping their own units. The internal mechanical solution of a Ratio System, producing dimensionless numbers, is preferred. The ratio system creates the opportunity to use a second approach: a Reference Point Theory, which uses the ratios of the ratio system. This overall theory is called MOORA (Multi-Objective Optimization by Ratio Analysis). The results are still more convincing if a Full Multiplicative Form is added forming MULTIMOORA. The control by three different approaches forms a guaranty for a solution being as non-subjective as possible. MULTIMOORA, tested after robustness, showed positive results.