In this paper, firstly, we propose two new GTHFNs-prioritized aggregation operators called generalized trapezoidal hesitant fuzzy number prioritized weighted average operator and generalized trapezoidal hesitant fuzzy number prioritized weighted geometric operator. Secondly, we investigate the fundamental properties of the operators in detail such as idempotency, boundedness and monotonicity. Thirdly, we propose a method based on the developed GTHF-numbers prioritized aggregation operators for solving an MADM problem with GTHF-numbers. Fourthly, we give a numerical example of the developed method. Finally, a comparative analysis is given with some existing methods in solving an MADM problem with GTHF-numbers.