This work compares different algorithms to replace the genetic optimizer used in a recent methodology for creating realistic and computationally efficient neuron models. That method focuses on single-neuron processing and has been applied to cerebellar granule cells. It relies on the adaptive-exponential integrate-and-fire (AdEx) model, which must be adjusted with experimental data. The alternatives considered are: i) a memetic extension of the original genetic method, ii) Differential Evolution, iii) Teaching-Learning-Based Optimization, and iv) a local optimizer within a multi-start procedure. All of them ultimately outperform the original method, and the last two do it in all the scenarios considered.