Computational Modeling of Bienzyme Biosensor with Different Initial and Boundary Conditions
Volume 24, Issue 4 (2013), pp. 505–521
Pub. online: 1 January 2013
Type: Research Article
Received
1 September 2012
1 September 2012
Accepted
1 February 2013
1 February 2013
Published
1 January 2013
1 January 2013
Abstract
Two mathematical models of an amperometric bienzyme biosensor are analysed digitally. The models hold different boundary conditions describing the singularity of the electrode (transducer). The influence of the initial and boundary conditions on the biosensors action at different sets of parameters is analysed.
The digital simulation at the transient and steady-state conditions was carried out by using finite difference technique. The comparison of the simulation results revealed that some of the calculated parameters, i.e. response and sensitivity is the same, while the others, i.e. half-time of the steady-state is significantly different for distinct models.