Informatica

Eye fundus imaging is a useful, non-invasive tool in disease progress tracking, in early detection of disease and other cases. Often, the disease diagnosis is made by an ophthalmologist and automatic analysis systems are used only for support. There are several commonly used features for disease detection, one of them is the artery and vein ratio measured according to the width of the main vessels. Arteries must be separated from veins automatically in order to calculate the ratio, therefore, vessel classification is a vital step. For most analysis methods high quality images are required for correct classification. This paper presents an adaptive algorithm for vessel measurements without the necessity to tune the algorithm for concrete imaging equipment or a specific situation. The main novelty of the proposed method is the extraction of blood vessel features based on vessel width measurement algorithm and vessel spatial dependency. Vessel classification accuracy rates of 0.855 and 0.859 are obtained on publicly available eye fundus image databases used for comparison with another state of the art algorithms for vessel classification in order to evaluate artery-vein ratio ($AVR$). The method is also evaluated with images that represent artery and vein size changes before and after physical load. Optomed OY digital mobile eye fundus camera Smartscope M5 PRO is used for image gathering.

In the usual statistical approach of spatial classification, it is assumed that the feature observations are independent conditionally on class labels (conditional independence). Discarding this popular assumption, we consider the problem of statistical classification by using multivariate stationary Gaussian Random Field (GRF) for modeling the conditional distribution given class labels of feature observations. The classes are specified by multivariate regression model for means and by common factorized covariance function. In the two-class case and for the class labels modeled by Random Field (RF) based on 0–1 divergence, the formula of the Expected Bayes Error Rate (EBER) is derived. The effect of training sample size on the EBER and the influence of statistical parameters to the values of EBER are numerically evaluated in the case when the spatial framework of data is the subset of the 2-dimensional rectangular lattice with unit spacing.