We consider the Multilevel Uncapacitated Facility Location Problem (MLUFLP) and propose a new efficient integer programming formulation of the problem that provides optimal solutions for the MLUFLP test instances unsolved to optimality up to now. Further, we design a parallel Memetic Algorithm (MA) with a new strategy for applying the local search improvement within the MA frame. The conducted computational experiments show that the proposed MA quickly reaches all known optimal and best known solutions from the literature and additionally improves several solutions for large-scale MLUFLP test problems.